Pharmtales.com
Lipitor: Pfizer's statin drug, highest-grossing blockbuster with $150B+ sales by 2017. Lowers cholesterol, prevents heart disease. Lost patent in 2011.
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Humira: AbbVie's biologic drug, $140B+ sales, treats inflammatory diseases like arthritis and psoriasis. Top-seller since 2015, patent expires in 2023.
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Plavix: Sanofi and Bristol Myers Squibb's antiplatelet drug, $100B+ sales. Prevents strokes and heart attacks. Widely prescribed, lost patent in 2012.
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Advair: GlaxoSmithKline's combo inhaler, $90B+ sales. Treats asthma and COPD. First respiratory drug to hit $10B sales. Lost patent in 2010 , some generic competition.
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Enbrel: Amgen and Pfizer's biologic drug, $80B+ sales. Treats inflammatory diseases like arthritis and psoriasis. Blockbuster status since 1998. Patent expires in US by 2029.
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Other drugs that made history